Meta-analysis of clinical trials with rare events.
نویسندگان
چکیده
Meta-analysis of rare event studies has recently become a subject of controversy and debate. We will argue and demonstrate in this paper that the occurrence of zero events in clinical trials or cohort studies, even if zeros occur in both arms (the case of a double-zero trial), is less problematic, at least from a statistical perspective, if the available statistical tools are applied in the appropriate way. In particular, it is neither necessary nor advisable to exclude studies with zero events from the meta-analysis. In terms of statistical tools, we will focus here on Mantel-Haenszel techniques, mixed Poisson regression and related regression models.
منابع مشابه
Efficacy of Prasaplai for Treatment of Primary Dysmenorrhea: a Meta-Analysis
Prasaplai is used in Thai traditional medicine for treatment of primary dysmenorrhea; however, clinical evidence is limited regarding the efficacy of Prasaplai for primary dysmenorrheal outcomes. This study has constituted a systematic review and meta-analysis to evaluate Prasaplai as an effective treatment for primary dysmenorrhea. Randomized controlled trials were retrieved and identified thr...
متن کاملA systematic review and meta-analysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters
Objective: We performed this systematic review and meta-analysis study to determine saffron (Crocus sativus) effectiveness and safety in male infertility problems. Materials and Methods: The databases PubMed, Scopus, Cochrane, Google Scholar, SID, IranMedex and Magiran until July 2016 and reference section of relevant articles, were searched to find both English and Persian clinical trials on m...
متن کاملSystematic review (Meta-analysis) of clinical trials on hair removal Lasers
Background: The theory of selective photo-thermolysis led to the development of a variety of different laser systems which range from the shorter spectrum of 694nm ruby laser to the middle with the 755nm alexandrite and 810nm diode lasers to the long end with the 1064nm (Nd:YAG) laser. Objective: A systematic review on the clinical trials with use of various laser sources for hair removal...
متن کاملTenecteplase versus reteplase in acute myocardial infarction: A network meta-analysis of randomized clinical trials
Background: Acute myocardial infarction (AMI) is the leading cause of death throughout the world. One of the standard approaches to treatment of AMI is fibrinolysis. The study was conducted to evaluate the clinical efficacy of tenecteplase versus reteplase through network meta-analysis for AMI. Methods: Randomized trials were comprehensively searched in PubMed, Scopus, Cochrane library, a...
متن کاملThe effect of quercetin on stress The Effect of Quercetin on Stress Oxidative Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trialsers; A systematic review and meta-analysis of randomized controlled clinical trials
Background: Quercetin is one of the main flavonoids, overall distributed in plants. The antioxidant capacity of quercetin is several times vitamin E and glutathione. This systematic review and meta‐analysis of randomized controlled trials were performed to determine the effect of quercetin on oxidative stress (OS) markers. Methods: A literature search was conducted in PubMed, ISI Web of Science...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biometrical journal. Biometrische Zeitschrift
دوره 57 4 شماره
صفحات -
تاریخ انتشار 2015